This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.

The CRMP Family of Proteins and Their Role in Sema3A Signaling.- GTPases in Semaphorin Signaling.- Intracellular Kinases in Semaphorin Signaling.- MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling.- Signaling of Secreted Semaphorins in Growth Cone Steering.- Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules.- Proteoglycans as Modulators of Axon Guidance Cue Function.- Semaphorin Signals in Cell Adhesion and Cell Migration: Functional Role and Molecular Mechanisms.- Semaphorin Signaling During Cardiac Development.- Semaphorin Signaling in Vascular and Tumor Biology.- Semaphorin Signaling in the Immune System.