Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular Biology¿ series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.

1. What is Cancer Nanotechnology?
Stephen R. Grobmyer, Nobutaka Iwakuma, Parvesh Sharma, and Brij M. Moudgil
2. Molecular Targeted Therapy for Cancer and Nanotechnology
Steven N. Hochwald
3. Enhanced Permeability and Retention (EPR) Effect for Anticancer Nano-Medicine Drug Targeting
Khaled Greish
4. Nanoparticle Characterization for Cancer Nanotechnology and Other Biological Applications
Scott C. Brown, Maria Palazuelos, Parvesh Sharma, Kevin W. Powers, Stephen M. Roberts, Stephen R. Grobmyer, and Brij M. Moudgil
5. Multimodal Nanoparticulate Bioimaging Contrast Agents
Parvesh Sharma, Amit Singh, Scott C. Brown, Niclas Bengtsson, Glenn A. Walter, Stephen R. Grobmyer, Nobutaka Iwakuma, Swadeshmukul Santra, Edward W. Scott, and Brij M. Moudgil
6. Gold Nanocages for Cancer Imaging and Therapy
Leslie Au, Jingyi Chen, Lihong V. Wang, and Younan Xia
7. Nanoshells for Photothermal Cancer Therapy
Jennifer G. Morton, Emily S. Day, Naomi J. Halas, and Jennifer L. West
8. Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy
Alexander Wei, Alexei P. Leonov, and Qingshan Wie
9. Polymeric Micelles: Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)-Based Micelles as an Example
Rupa R. Sawant and Vladimir P. Torchilin
10. Fluorescent Silica Nanoparticles for Cancer Imaging
Swadeshmukul Santra
11. Polymeric Nanoparticles for Drug Delivery
Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, and Omid C. Farokhzad
12. Synthesis, Characterization, and Functionalization of Gold Nanoparticles for Cancer Imaging
Gary A. Craig, Peter J. Allen, and Michael D. Mason
13. Identification of Pancreatic Cancer Specific Cell-Surface Markers for Development of Targeting Ligands
David L. Morse, Galen Hostetter, Yoganand Balagurunathan, Robert J. Gillies, and Haiyong Han
14. Preparation and Characterization of Doxorubicin Liposomes
Guoqin Niu, Brian Cogburn, and Jeffrey Hughes
15. PEGylated Nanocarriers for Systemic Delivery
N.K. Jain and Manoj Nahar
16. Nanoparticle-Aptamer Conjugates for Cancer Cell Targeting and Detection
M.-Carmen Estevez, Yu-Fen Huang, Huaizhi Kang, Megan B. O¿Donoghue, Suwussa Bamrungsap, Jilin Yan, Xiaolan Chen, and Weihong Tan
17. Targeting of Nanoparticles: Folate Receptor
Sumith A. Kularatne and Philip S. Low
18. Magnetic Aerosol Targeting of Nanoparticles to Cancer: Nanomagnetosols
Carsten Rudolph, Bernhard Gleich, and Andreas W. Flemmer
19. LHRH-Targeted Nanoparticles for Cancer Therapeutics
Tamara Minko, Mahesh L. Patil, Min Zhang, Jayant J. Khandare, Maha Saad, Pooja Chandna, and Oleh Taratula
20. Antibody Targeting of Nanoparticles to Tumor Specific Receptors: Immunoliposomes
Miriam Rothdiener, Julia Beuttler, Sylvia K.E. Messerschmidt, and Roland E. Kontermann
21. Photoacoustic Tomography for Imaging Nanoparticles
Zhen Yuan and Huabei Jiang
22. Current Applications of Nanotechnology for Magnetic Resonance Imaging of Apoptosis
Gustav J. Strijkers, Geralda A.F. van Tilborg, Tessa Geelen, Chris P.M. Reutelingsperger, and Klaas Nicolay
23. Applications of Gold Nanorods for Cancer Imaging and Photothermal Therapy
Xiaohua Huang, Ivan H. El-Sayed, and Mostafa A. El-Sayed
24. Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells
Paul Cherukuri and Steven A. Curley
25. Colloidal Gold: A Novel Nanoparticle for Targeted Cancer Therapeutics
Anathea C. Powell, Giulio F. Paciotti, and Steven K. Libutti
26. Liposomal Doxorubicin and